Article
Candidate long-range regulatory sites acting on the IL17 pathway genes TRAF3IP2 and IL17RA are associated with psoriasis.
Experimental dermatology - 1 Nov 2018
Nititham Joanne, Fergusson Calum, Palmer Colin, Liao Wilson, Foerster John
Abstract excerpt
BACKGROUND: Drug-mediated disruption of IL17A, IL17F and IL17RA proteins is effective in psoriasis. However, disruption of the IL17 pathway by functional mutations has so far only been shown to affect risk in IL23R and TRAF3IP2. It is unclear whether this is due to rarity of disruptive mutations. OBJECTIVE: (a) To delineate the prevalence of mutations in key IL17 pathway genes and (b) to identify candidate...
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