Article
Insulin-like growth factor-binding protein 3 inhibits angiotensin II-induced aortic smooth muscle cell phenotypic switch and matrix metalloproteinase expression.
Experimental physiology - 1 Nov 2020
Chen Suwei, Chen Hong, Zhong Yongliang, Ge Yipeng, Li Chengnan, Qiao Zhiyu, Zhu Junming
Abstract excerpt
NEW FINDINGS: What is the central question of this study? Insulin-like growth factor 1 and its major binding protein insulin-like growth factor binding protein 3 (IGFBP3) are involved in collagen deregulation in several cardiovascular diseases: what is the role of IGFBP3 in thoracic aortic dissection and does it regulate aortic smooth muscle cells' phenotypic switch? What is the main finding and its importance?...
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