Article
Nuclear receptor corepressor 1 levels differentially impact the intracellular dynamics of mutant thyroid hormone receptors associated with resistance to thyroid hormone syndrome.
Molecular and cellular endocrinology - 1 Dec 2024
Simsek Yigit K, Tofil H Page, Rosenthal Matthew I, Evans Rochelle M, Danielski Caroline L, Beasley Katelyn E, Alsayed Haytham, Shapira Molly E, Strauss Rebecca I, Wang Moyao, Roggero Vincent R, Allison Lizabeth A
Abstract excerpt
Thyroid hormone receptor α1 (TRα1) undergoes nucleocytoplasmic shuttling and mediates gene expression in response to thyroid hormone (T3). In Resistance to Thyroid Hormone Syndrome α (RTHα), certain TRα1 mutants have higher affinity for nuclear corepressor 1 (NCoR1) and may form stable complexes that are not released in the presence of T3. Here, we examined whether NCoR1 modulates intranuclear mobility and...
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