Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Resistance to thyroid hormone due to defective thyroid receptor alpha.

Best practice & research. Clinical endocrinology & metabolism - 1 Aug 2015

Moran Carla, Chatterjee Krishna

Abstract excerpt

Thyroid hormones act via nuclear receptors (TRα1, TRβ1, TRβ2) with differing tissue distribution; the role of α2 protein, derived from the same gene locus as TRα1, is unclear. Resistance to thyroid hormone alpha (RTHα) is characterised by tissue-specific hypothyroidism associated with near-normal thyroid function tests. Clinical features include dysmorphic facies, skeletal dysplasia (macrocephaly, epiphyseal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Growth Hormone and Insulin-like Growth Factors
Share to Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Phenotype

Share to Thyroid Cancer Diagnosis and Treatment

Share to Thyroid Disorders and Treatments

Share to Thyroid Hormone Receptors alpha

Share to Thyroid Hormone Resistance Syndrome

Share to Thyroid Hormones

Source

Open in PubMed Open full text

Identifiers

PMID: 26303090
DOI: 10.1016/j.beem.2015.07.007
PMCID: PMC4559105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Resistance to thyroid hormone due to defective thyroid receptor alpha.PMID 26303090Read ↗

Resistance to thyroid hormone mediated by defective thyroid hormone receptor alpha.Semantic proximity Read ↗

Resistance to thyroid hormone caused by a mutation in thyroid hormone receptor (TR)α1 and TRα2: clinical, biochemical, and genetic analyses of three related patientsSemantic proximity Read ↗

Thyroid hormone resistance syndrome due to mutations in the thyroid hormone receptor α gene (THRA).Semantic proximity Read ↗

Contrasting Phenotypes in Resistance to Thyroid Hormone Alpha Correlate with Divergent Properties of Thyroid Hormone Receptor α1 Mutant Proteins.Semantic proximity Read ↗

Resistance to thyroid hormone α, revelation of basic study to clinical consequences.Semantic proximity Read ↗

TRα receptor mutations extend the spectrum of syndromes of reduced sensitivity to thyroid hormone.Semantic proximity Read ↗

A Novel Mutation in THRA Gene Associated With an Atypical Phenotype of Resistance to Thyroid Hormone.Semantic proximity Read ↗

Resistance to Thyroid Hormone due to Heterozygous Mutations in Thyroid Hormone Receptor Alpha.Semantic proximity Read ↗

Diverse Genotypes and Phenotypes of Three Novel Thyroid Hormone Receptor-α Mutations.Semantic proximity Read ↗

Human Genetics of Thyroid Hormone Receptor Beta: Resistance to Thyroid Hormone Beta (RTHβ).Semantic proximity Read ↗

A clinician’s guide to understanding resistance to thyroid hormone due to receptor mutations in the TRα and TRβ isoformsSemantic proximity Read ↗

Resistance to thyroid hormone.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.