Nuclear cytoplasmic shuttling by thyroid hormone receptors. multiple protein interactions are required for nuclear retention.

doi:10.1074/jbc.M011112200

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Article

Nuclear cytoplasmic shuttling by thyroid hormone receptors. multiple protein interactions are required for nuclear retention.

The Journal of biological chemistry - 6 Apr 2001

Baumann C T, Maruvada P, Hager G L, Yen P M

Abstract excerpt

In this report, we have studied the intracellular dynamics and distribution of the thyroid hormone receptor-beta (TRbeta) in living cells, utilizing fusions to the green fluorescent protein. Wild-type TRbeta was mostly nuclear in both the absence and presence of triiodothyronine; however, triiodothyronine induced a nuclear reorganization of TRbeta. By mutating defined regions of TRbeta, we found that both nuclear...

Topics

Biological Transport
Cell Nucleus
Cytoplasm
DNA
HeLa Cells
Humans
Mutation
Protein Binding
Receptors, Thyroid Hormone
Signal Transduction
Transfection

Source

Open in PubMed

Identifiers

PMID: 11152480
DOI: 10.1074/jbc.M011112200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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