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Article

Molecular variations in Klebsiella pneumoniae and Escherichia coli FimH affect function and pathogenesis in the urinary tract.

Infection and immunity - 1 Jul 2008

Rosen David A, Pinkner Jerome S, Walker Jennifer N, Elam Jennifer Stine, Jones Jennifer M, Hultgren Scott J

Abstract excerpt

Type 1 pili mediate binding, invasion, and biofilm formation of uropathogenic Escherichia coli (UPEC) in the host urothelium during urinary tract infection (UTI) via the adhesin FimH. In this study, we characterized the molecular basis of functional differences between FimH of the UPEC isolate UTI89 and the Klebsiella pneumoniae cystitis isolate TOP52. Type 1 pili characteristically mediate mannose-sensitive...

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Identifiers

PMID: 18474655
DOI: 10.1128/IAI.00340-08
PMCID: PMC2446687

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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