Divergent regulation of virulence factors by FimK in classical and hypervirulent Klebsiella pneumoniae pathotypes.

Abstract excerpt

Klebsiella pneumoniae is an opportunistic bacterial pathogen that is increasingly recognized as a major global threat. Type 1 pili, encoded by the fim operon, are virulence factors imperative in K. pneumoniae urinary tract infection. FimK, a regulatory protein, has been shown to repress type 1 fimbrial expression in specific K. pneumoniae strains, but its role across diverse K. pneumoniae pathotypes has not been...

Topics

• Klebsiella pneumoniae
• Virulence Factors
• Gene Expression Regulation, Bacterial
• Virulence
• Fimbriae, Bacterial
• Klebsiella Infections