Article
Ultraslow conformational dynamics and catch bond formation of a bacterial adhesin revealed by a single-domain variant of FimH.
Proceedings of the National Academy of Sciences of the United States of America - 2 Jun 2026
Magala Pearl, Tuttle Lisa M, Interlandi Gianluca, Carlucci Laura A, Mollica Molly Y, Janowska Maria K, Thomas Wendy E, Sokurenko Evgeni V, Klevit Rachel E
Abstract excerpt
Bacterial fimbrial adhesins such as FimH are critical for host colonization and persistence under the mechanical forces encountered at sites of infection such as the urinary tract. The molecular mechanisms by which FimH, a key virulence factor of uropathogenic Escherichia coli, regulates its binding to host cell surface mannose moieties through conformational switching remain incompletely understood. FimH...
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