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Interactions between polycyclic aromatic hydrocarbons and genetic variants in the cGAS-STING pathway affect the risk of colorectal cancer.

Archives of toxicology - 1 Dec 2024

Zhou Jieyu, Li Dongzheng, Xu Menghuan, Zhu Tianru, Li Zhengyi, Fu Zan, Wang Meilin, Li Shuwei, Gu Dongying

Abstract excerpt

The cGAS-STING pathway plays an essential role in the activation of tumor immune cells. Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants with potential carcinogenicity, and their exposure is associated with the development of colorectal cancer. However, the impacts of genetic factors in the cGAS‒STING pathway and gene‒environment interactions on colorectal cancer remain understudied. We used...

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PMID: 39287666
DOI: 10.1007/s00204-024-03862-8

Genes

TRAF2

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