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Article

IκBKβ and NFκB1, NSAID use and risk of colorectal cancer in the Colon Cancer Family Registry.

Carcinogenesis - 1 Jan 2013

Seufert Brenna L, Poole Elizabeth M, Whitton John, Xiao Liren, Makar Karen W, Campbell Peter T, Kulmacz Richard J, Baron John A, Newcomb Polly A, Slattery Martha L, Potter John D, Ulrich Cornelia M

Abstract excerpt

The NFκB-signaling pathway regulates cell proliferation and inflammation. Activation of the pathway is implicated in the etiology of colorectal cancer (CRC). NSAIDs may reduce CRC risk partially through a nuclear factor-kappa B (NFκB)-dependent pathway. In this study, we investigated associations between 34 NFκB1 and 8 IκBKβ tagSNPs and CRC risk and examined interactions with non-steroidal anti-inflammatory drug...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23002237
DOI: 10.1093/carcin/bgs296
PMCID: PMC3534188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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