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Article

A Multimodal, In Vivo Approach for Assessing Structurally and Phenotypically Related Neuroactive Molecules.

ACS chemical neuroscience - 20 Nov 2024

McCarroll Matthew N, Sisko Elizabeth, Gong Jung Ho, Teng Jinfeng, Taylor Jack, Myers-Turnbull Douglas, Young Drew, Burley Grant, Pierce Lain X, Hibbs Ryan E, Kokel David, Sello Jason K

Abstract excerpt

A recently reported behavioral screen in larval zebrafish for phenocopiers of known anesthetics and associated drugs yielded an isoflavone. Related isoflavones have also been reported as GABAA potentiators. From this, we synthesized a small library of isoflavones and incorporated an in vivo phenotypic approach to perform structure-behavior relationship studies of the screening hit and related analogs via...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39287508
DOI: 10.1021/acschemneuro.4c00426
PMCID: PMC11587515

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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