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Validation, optimization, and quality assessment of a neuro-behavioral in vivo assay for phenotypic high-content evaluation of anesthetics.

SLAS discovery : advancing life sciences R & D - 1 Dec 2025

Zupanc Günther K H, Ahmed Mariam

Abstract excerpt

In vivo assays based on aquatic model organisms have played a pivotal role in the development of anesthetics and their pharmacological and physiological characterization. They have been designed primarily as cost-effective tools for initial screening of compounds, prioritizing high throughput and simple measurement of a behavioral readout. Common limitations include manual recoding and analysis of behavioral...

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PMID: 41480954
DOI: 10.1016/j.slasd.2025.100285

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