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Article

JM-20 potently prevents the onset of caffeine-induced anxiogenic phenotypes in zebrafish (Danio rerio).

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP - 1 Mar 2024

Dos Santos Matheus Mülling, Ferreira Sabrina Antunes, de Macedo Gabriel Teixeira, Claro Mariana Torri, Müller Talise Ellwanger, Prestes Alessandro de Souza, da Rocha João Batista Teixeira, Núñez-Figueredo Yanier, Barbosa Nilda de Vargas

Abstract excerpt

Anxiety is among the most prevalent mental disorders present in the general population. Benzodiazepines are the most commonly prescribed drugs for the treatment of anxiety. Using zebrafish as a model organism, we investigated the anxiolytic activity of JM-20, a novel hybrid molecule with a 1,5-benzodiazepine ring fused to a dihydropyridine moiety. Firstly, we carried out some assays to analyze the possible...

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Identifiers

PMID: 38237841
DOI: 10.1016/j.cbpc.2024.109843

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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