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Article

Polygene by environment interactions predicting depressive outcomes.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jan 2025

Grillo Alessandra R

Abstract excerpt

Depression is a major public health problem with a continued need to uncover its etiology. Current models of depression contend that gene-by-environment (G × E) interactions influence depression risk, and further, that depression is polygenic. Thus, recent models have emphasized two polygenic approaches: a hypothesis-driven multilocus genetic profile score (MGPS; "MGPS × E") and a polygenic risk score (PRS;...

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Depression
Depressive Disorder
Gene-Environment Interaction
Genetic Predisposition to Disease
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multifactorial Inheritance

Stress, Psychological

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PMID: 39012198
DOI: 10.1002/ajmg.b.33000

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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