Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants.

Molecular psychiatry - 1 Jan 2025

Kanjira S C, Adams M J, Jiang Y, Tian C, Lewis C M, Kuchenbaecker K, McIntosh A M

Abstract excerpt

Genome-Wide Association Studies (GWAS) over-represent European ancestries, neglecting all other ancestry groups and low-income nations. Consequently, polygenic risk scores (PRS) more accurately predict complex traits in Europeans than African Ancestries groups. Very few studies have looked at the transferability of European-derived PRS for behavioural and mental health phenotypes to Africans. We assessed the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black People
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Depressive Disorder, Major

Share to Genetic Risk Score

Share to Genome-Wide Association Study

Share to UK Biobank

Share to United Kingdom

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 39014000
DOI: 10.1038/s41380-024-02662-x
PMCID: PMC11649553

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants.PMID 39014000Read ↗

Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participantsSemantic proximity Read ↗

Multiple measures of depression to enhance validity of Major Depressive Disorder in the UK BiobankSemantic proximity Read ↗

Multiple measures of depression to enhance validity of major depressive disorder in the UK BiobankSemantic proximity Read ↗

Depression Genetics in Africa (DepGenAfrica): protocol for the first large-scale case-control study of major depressive disorder among continental AfricansSemantic proximity Read ↗

Depression Genetics in Africa (DepGenAfrica): protocol for the first large-scale case-control study of major depressive disorder among continental AfricansSemantic proximity Read ↗

Using Major Depression Polygenic Risk Scores to Explore the Depressive Symptom ContinuumSemantic proximity Read ↗

Polygenic risk scores for disease risk prediction in Africa: current challenges and future directions.Semantic proximity Read ↗

Polygenic Risk Scores Derived From Varying Definitions of Depression and Risk of Depression.Semantic proximity Read ↗

Genetic effects influencing risk for major depressive disorder in China and Europe.Semantic proximity Read ↗

Genetic architecture and socio-environmental risk factors for major depressive disorder in Nepal.Semantic proximity Read ↗

Genetic liability estimated from large-scale family data improves genetic prediction, risk score profiling, and gene mapping for major depression.Semantic proximity Read ↗

The Australian Genetics of Depression Study: New Risk Loci and Dissecting Heterogeneity Between Subtypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.