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Article

CRISPR-enabled point-of-care genotyping for APOL1 genetic risk assessment.

EMBO molecular medicine - 1 Oct 2024

Greensmith Robert, Lape Isadora T, Riella Cristian V, Schubert Alexander J, Metzger Jakob J, Dighe Anand S, Tan Xiao, Hemmer Bernhard, Rau Josefine, Wendlinger Sarah, Diederich Nora, Schütz Anja, Riella Leonardo V, Kaminski Michael M

Abstract excerpt

Detecting genetic variants enables risk factor identification, disease screening, and initiation of preventative therapeutics. However, current methods, relying on hybridization or sequencing, are unsuitable for point-of-care settings. In contrast, CRISPR-based-diagnostics offer high sensitivity and specificity for point-of-care applications. While these methods have predominantly been used for pathogen sensing,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39271961
DOI: 10.1038/s44321-024-00126-x
PMCID: PMC11473833

Genes

APOL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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