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Article

CRISPR-Based Assay for Point-of-Care Pharmacogenetic CYP2C19 Genotyping.

ACS sensors - 24 Jul 2026

Schubert Alexander J, Meng Qiyao, Hoffmann Joshua, Rau Josefine, Abele Fabian, Greensmith Robert, Cordero Carlos, Ibel Antonia, Mandler Julia M, Eckardt Kai-Uwe, Halbritter Jan, Dighe Anand S, Tan Xiao, Hwang Daw-Yang, Petzold Tobias, Enghard Philipp, Kaminski Michael M

Abstract excerpt

Pharmacogenetic testing enables personalized drug dosing by accounting for genetic variation in drug metabolism. Although there is increasing evidence that genetically guided dosing improves therapeutic efficacy and reduces adverse effects, clinical implementation remains limited as genotyping methods suffer from slow turnaround times and are not optimized for point-of-care use. Here, we present a rapid,...

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Identifiers

PMID: 42345496
DOI: 10.1021/acssensors.6c00841

Genes

CYP2C19

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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