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Article

HIV-1 adapts to lost IP6 coordination through second-site mutations that restore conical capsid assembly.

Nature communications - 13 Sept 2024

Kleinpeter Alex, Mallery Donna L, Renner Nadine, Albecka Anna, Klarhof J Ole, Freed Eric O, James Leo C

Abstract excerpt

The HIV-1 capsid is composed of capsid (CA) protein hexamers and pentamers (capsomers) that contain a central pore hypothesised to regulate capsid assembly and facilitate nucleotide import early during post-infection. These pore functions are mediated by two positively charged rings created by CA Arg-18 (R18) and Lys-25 (K25). Here we describe the forced evolution of viruses containing mutations in R18 and K25....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39271696
DOI: 10.1038/s41467-024-51971-w
PMCID: PMC11399258

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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