Article
Fitness costs of mutations at the HIV-1 capsid hexamerization interface.
PloS one - 1 Jan 2013
Manocheewa Siriphan, Swain J Victor, Lanxon-Cookson Erinn, Rolland Morgane, Mullins James I
Abstract excerpt
The recently available x-ray crystal structure of HIV-1 capsid hexamers has provided insight into the molecular interactions crucial for the virus's mature capsid formation. Amino acid changes at these interaction points are likely to have a strong impact on capsid functionality and, hence, viral infectivity and replication fitness. To test this hypothesis, we introduced the most frequently observed single amino...
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