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Paracrine roles of cellular senescence in promoting tumourigenesis

17 Apr 2018

Abstract excerpt

Senescent cells activate genetic programmes that irreversibly inhibit cellular proliferation, but also endow these cells with distinctive metabolic and signalling phenotypes. Although senescence has historically been considered a protective mechanism against tumourigenesis, the activities of senescent cells are increasingly being associated with age-related diseases, including cancer. An important feature of...

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PMID: 29670296
DOI: 10.1038/s41416-018-0066-1

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