Article
FHOD-1 and profilin protect sarcomeres against contraction-induced deformation> in C. elegans.
Molecular biology of the cell - 1 Nov 2024
Kimmich Michael J, Sundaramurthy Sumana, Geary Meaghan A, Lesanpezeshki Leila, Yingling Curtis V, Vanapalli Siva A, Littlefield Ryan S, Pruyne David
Abstract excerpt
Formin HOmology Domain 2-containing (FHOD) proteins are a subfamily of actin-organizing formins important for striated muscle development in many animals. We showed previously that absence of the sole FHOD protein, FHOD-1, from Caenorhabditis elegans results in thin body wall muscles with misshapen dense bodies that serve as sarcomere Z-lines. We demonstrate here that mutations predicted to specifically disrupt...
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