Conditional dominant mutations in the Caenorhabditis elegans gene act-2 identify cytoplasmic and muscle roles for a redundant actin isoform.

doi:10.1091/mbc.e05-09-0886

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Article

Conditional dominant mutations in the Caenorhabditis elegans gene act-2 identify cytoplasmic and muscle roles for a redundant actin isoform.

Molecular biology of the cell - 1 Mar 2006

Willis John H, Munro Edwin, Lyczak Rebecca, Bowerman Bruce

Abstract excerpt

Animal genomes each encode multiple highly conserved actin isoforms that polymerize to form the microfilament cytoskeleton. Previous studies of vertebrates and invertebrates have shown that many actin isoforms are restricted to either nonmuscle (cytoplasmic) functions, or to myofibril force generation in muscle cells. We have identified two temperature-sensitive and semidominant embryonic-lethal Caenorhabditis...

Topics

Actin Cytoskeleton
Actins
Alleles
Amino Acid Sequence
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cell Division
Cell Polarity
Cell Surface Extensions
Cytoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Embryo, Nonmammalian

Embryonic Development

Genes, Dominant

Genes, Helminth

Molecular Sequence Data

Muscles

Mutation

Source

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Identifiers

PMID: 16407404
DOI: 10.1091/mbc.e05-09-0886
PMCID: PMC1382297

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