Article
Defining the transcriptional redundancy of early bodywall muscle development in C. elegans: evidence for a unified theory of animal muscle development.
Genes & development - 15 Dec 2006
Fukushige Tetsunari, Brodigan Thomas M, Schriefer Lawrence A, Waterston Robert H, Krause Michael
Abstract excerpt
Myogenic regulatory factors (MRFs) are required for mammalian skeletal myogenesis. In contrast, bodywall muscle is readily detectable in Caenorhabditis elegans embryos lacking activity of the lone MRF ortholog HLH-1, indicating that additional myogenic factors must function in the nematode. We find that two additional C. elegans proteins, UNC-120/SRF and HND-1/HAND, can convert naïve blastomeres to muscle when...
Topics
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Biological Evolution
- Blastomeres
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Differentiation
- Gene Expression Regulation, Developmental
- MADS Domain Proteins
- Muscle Cells
- Muscle Development
- Muscle Proteins