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Article

Defining the transcriptional redundancy of early bodywall muscle development in C. elegans: evidence for a unified theory of animal muscle development.

Genes & development - 15 Dec 2006

Fukushige Tetsunari, Brodigan Thomas M, Schriefer Lawrence A, Waterston Robert H, Krause Michael

Abstract excerpt

Myogenic regulatory factors (MRFs) are required for mammalian skeletal myogenesis. In contrast, bodywall muscle is readily detectable in Caenorhabditis elegans embryos lacking activity of the lone MRF ortholog HLH-1, indicating that additional myogenic factors must function in the nematode. We find that two additional C. elegans proteins, UNC-120/SRF and HND-1/HAND, can convert naïve blastomeres to muscle when...

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PMID: 17142668
DOI: 10.1101/gad.1481706
PMCID: PMC1698447

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