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Article

Integrated analyses reveal two molecularly and clinically distinct subtypes of H3 K27M-mutant diffuse midline gliomas with prognostic significance.

Acta neuropathologica - 10 Sept 2024

Stegat Lotte, Eckhardt Alicia, Gocke Antonia, Neyazi Sina, Pohl Lara, Schmid Simone, Dottermusch Matthias, Frank Stephan, Pinnschmidt Hans, Herms Jochen, Glatzel Markus, Snuderl Matija, Schweizer Leonille, Thomas Christian, Neumann Julia, Dorostkar Mario M, Schüller Ulrich, Wefers Annika K

Abstract excerpt

H3 K27M-altered diffuse midline gliomas (DMGs) are highly malignant tumours that arise in the midline structures of the CNS. Most DMGs carry an H3 K27M-mutation in one of the genes encoding for histone H3. Recent studies suggested that epigenetic subgroups of DMGs can be distinguished based on alterations in the MAPK-signalling pathway, tumour localisation, mutant H3-gene, or overall survival (OS). However, as...

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Identifiers

PMID: 39256213
DOI: 10.1007/s00401-024-02800-3
PMCID: PMC11387453

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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