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Article

PDE4B Missense Variant Increases Susceptibility to Post-traumatic Stress Disorder-Relevant Phenotypes in Mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 23 Oct 2024

Lipina Tatiana V, Li Shupeng, Petrova Ekaterina S, Amstislavskaya Tamara G, Cameron Ryan T, Elliott Christina, Gondo Yoichi, McGirr Alexander, Mullins Jonathan G L, Baillie George S, Woodgett James R, Clapcote Steven J

Abstract excerpt

Large-scale genome-wide association studies (GWASs) have associated intronic variants in PDE4B, encoding cAMP-specific phosphodiesterase-4B (PDE4B), with increased risk for post-traumatic stress disorder (PTSD), as well as schizophrenia and substance use disorders that are often comorbid with it. However, the pathophysiological mechanisms of genetic risk involving PDE4B are poorly understood. To examine the...

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Share to Cyclic Nucleotide Phosphodiesterases, Type 4
Share to Fear

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to Mice, Inbred C57BL

Share to Mutation, Missense

Share to Reflex, Startle

Share to Stress Disorders, Post-Traumatic

Source

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Identifiers

PMID: 39256048
DOI: 10.1523/JNEUROSCI.0137-24.2024
PMCID: PMC11502227

Genes

PDE4B
BDNF

Variants

rs775201287

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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