Article
Whole-genome sequence analysis of morphological changes in Haemophilus influenzae after beta-lactam exposure.
Journal of global antimicrobial resistance - 1 Dec 2024
Malisova Lucia, Jakubu Vladislav, Bitar Ibrahim, Krsek Daniel, Zemlickova Helena
Abstract excerpt
This report describes mutations in genes responsible for cell deformities in haemophili under beta-lactam pressure in vitro. Light and transmission electron microscopy confirmed a hypothesis regarding changes in the shape of haemophili that had become more filamentous in the presence of ampicillin (2 mg/L) and cefuroxime (8 mg/L) after 30 days of serial passage. Short-axis size increased by 28% (from 0.767 to...
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