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In vivocardiac reprogramming using an optimal single polycistronic construct: Figure 1

23 Sept 2015

Abstract excerpt

Direct cardiac reprogramming holds great promise for cardiac regeneration and disease modelling.1–15 We recently reported that stoichiometry of Gata4 (G), Mef2c (M), and Tbx5 (T) influences the efficiency and quality of induced cardiomyocyte (iCM) reprogramming.16 We generated a full set of polycistronic vectors to manipulate the relative levels of G, M, and T protein expression. Among the six combinations, MGT...

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PMID: 26400236
DOI: 10.1093/cvr/cvv223

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