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Article

Phosphorylation of cytosolic hPGK1 affects protein stability and ligand binding: implications for its subcellular targeting in cancer.

The FEBS journal - 1 Nov 2024

Pacheco-García Juan Luis, Cano-Muñoz Mario, Loginov Dmitry S, Vankova Pavla, Man Petr, Pey Angel L

Abstract excerpt

Human phosphoglycerate kinase 1(hPGK1) is a key glycolytic enzyme that regulates the balance between ADP and ATP concentrations inside the cell. Phosphorylation of hPGK1 at S203 and S256 has been associated with enzyme import from the cytosol to the mitochondria and the nucleus respectively. These changes in subcellular locations drive tumorigenesis and are likely associated with site-specific changes in protein...

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PMID: 39240559
DOI: 10.1111/febs.17262

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