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Article

Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations.

Nature - 2 Jul 2015

Webb Bradley A, Forouhar Farhad, Szu Fu-En, Seetharaman Jayaraman, Tong Liang, Barber Diane L

Abstract excerpt

Phosphofructokinase-1 (PFK1), the 'gatekeeper' of glycolysis, catalyses the committed step of the glycolytic pathway by converting fructose-6-phosphate to fructose-1,6-bisphosphate. Allosteric activation and inhibition of PFK1 by over ten metabolites and in response to hormonal signalling fine-tune glycolytic flux to meet energy requirements. Mutations inhibiting PFK1 activity cause glycogen storage disease type...

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Identifiers

PMID: 25985179
DOI: 10.1038/nature14405
PMCID: PMC4510984

Genes

PFKP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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