Article
The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation.
Bioscience reports - 28 Feb 2018
Nawaz Mir Hussain, Ferreira Juliana C, Nedyalkova Lyudmila, Zhu Haizhong, Carrasco-López César, Kirmizialtin Serdal, Rabeh Wael M
Abstract excerpt
The high proliferation rate of tumor cells demands high energy and metabolites that are sustained by a high glycolytic flux known as the 'Warburg effect'. The activation and further metabolism of glucose is initiated by hexokinase, a focal point of metabolic regulation. The human hexokinase 2 (HK2) is overexpressed in all aggressive tumors and predominantly found on the outer mitochondrial membrane, where...
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