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Article

Novel mutation in hexokinase 2 confers resistance to 2-deoxyglucose by altering protein dynamics.

PLoS computational biology - 1 Mar 2022

Hellemann Erich, Walker Jennifer L, Lesko Mitchell A, Chandrashekarappa Dakshayini G, Schmidt Martin C, O'Donnell Allyson F, Durrant Jacob D

Abstract excerpt

Glucose is central to many biological processes, serving as an energy source and a building block for biosynthesis. After glucose enters the cell, hexokinases convert it to glucose-6-phosphate (Glc-6P) for use in anaerobic fermentation, aerobic oxidative phosphorylation, and the pentose-phosphate pathway. We here describe a genetic screen in Saccharomyces cerevisiae that generated a novel spontaneous mutation in...

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Identifiers

PMID: 35235554
DOI: 10.1371/journal.pcbi.1009929
PMCID: PMC8920189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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