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Article

Different phenotypic outcome due to site-specific phosphorylation in the cancer-associated NQO1 enzyme studied by phosphomimetic mutations.

Archives of biochemistry and biophysics - 30 Oct 2022

Pacheco-Garcia Juan Luis, Anoz-Carbonell Ernesto, Loginov Dmitry S, Vankova Pavla, Salido Eduardo, Man Petr, Medina Milagros, Palomino-Morales Rogelio, Pey Angel L

Abstract excerpt

Protein phosphorylation is a common phenomenon in human flavoproteins although the functional consequences of this site-specific modification are largely unknown. Here, we evaluated the effects of site-specific phosphorylation (using phosphomimetic mutations at sites S40, S82 and T128) on multiple functional aspects as well as in the structural stability of the antioxidant and disease-associated human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36096178
DOI: 10.1016/j.abb.2022.109392

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