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Article

Genetic regulation of B cell receptor signaling pathway: Insights from expression quantitative trait locus analysis using a mixed model.

Computational biology and chemistry - 1 Dec 2024

Bae Hojin, Jeon Hyowon, Lee Chaeyoung

Abstract excerpt

The B cell receptor (BCR) signaling pathway regulates non-immune cellular response through various pathways like MAPK, NF-kB, and PI3K-Akt. This study aimed to identify expression quantitative trait loci (eQTL) and their regulatory functions on BCR signaling pathway genes. A mixed model was employed to analyze eQTL using RNA expression levels in lymphoblastoid from 376 Europeans in the GEUVADIS dataset. In total,...

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Share to BCR gene
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Share to Receptors, Antigen, B-Cell

Share to Signal Transduction

Source

Identifiers

PMID: 39236423
DOI: 10.1016/j.compbiolchem.2024.108188

Genes

BCR
PLCG2
SYK
VAV2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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