Article
Impaired TGF-β signaling via AHNAK family mutations elicits an esophageal cancer subtype with sensitivities to genotoxic therapy and immunotherapy.
Cancer immunology, immunotherapy : CII - 5 Sept 2024
Mai Zihang, Kongjia Luo, Wang Xinye, Xie Xiuying, Pang Lanlan, Yang Hong, Wen Jing, Fu Jianhua
Abstract excerpt
BACKGROUND: Genome instability (GI) is a hallmark of esophageal squamous cell carcinoma (ESCC) while factors affecting GI remain unclear. METHODS: Here, we aimed to characterize genomic events representing specific mechanisms of GI based on 201 ESCC samples and validated our findings at the patient, single-cell and cancer cell-line levels, including a newly generated multi-omics dataset of the trial NCT04006041....
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