Article
Circulating apoE4 protein levels from dried blood spots predict cognitive function in a large population-based survey setting.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2024
Deza-Lougovski Yacila I, Weiss Luzia M, Horton Hannah M, Sun Aijing, Borbye-Lorenzen Nis, Skogstrand Kristin, Holmgaard Solveig, Andersen-Ranberg Karen, Lundmark Vania Panes, Börsch-Supan Axel, Börsch-Supan Martina, Rieckmann Anna
Abstract excerpt
INTRODUCTION: The apolipoprotein E (APOE) ε4 allele carries risk for cognitive impairment, but whether the level of circulating apoE4 protein in carriers affects cognition is unclear, as is how health and lifestyle impact circulating apoE4 levels. METHODS: We assayed apoE4 protein levels in dried blood spots of 12,532 adults aged 50+. Regression analyses tested the likelihood of cognitive impairment between...
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