Article
Cooperative induction of rat mammary cancer by radiation and 1-methyl-1-nitrosourea via the oncogenic pathways involving c-Myc activation and H-ras mutation.
International journal of cancer - 10 Jun 2005
Imaoka Tatsuhiko, Nishimura Mayumi, Teramoto Ayako, Nishimura Yukiko, Ootawara Masami, Osada Harumi, Kakinuma Shizuko, Maekawa Akihiko, Shimada Yoshiya
Abstract excerpt
Humans are continually exposed to various environmental carcinogens. Cancers may arise as a result of exposure to carcinogenic chemicals, ionizing radiation or a combination thereof. However, the mechanism of combined carcinogenesis has been only deduced from oncogenic actions of individual agents. Here, we analyzed experimental mammary carcinogenesis caused by a combination of radiation and a chemical...
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