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Article

Intra-host SARS-CoV-2 diversity in immunocompromised people living with HIV provides insight into the evolutionary trajectory of SARS-CoV-2.

Journal of virology - 23 Oct 2025

Joseph R, Marais G, Iranzadeh I, Alisoltani A, Hardie D, Davies M-A, Heekes A, Chetty N, Timmerman V, Hsiao N-Y, Williamson C

Abstract excerpt

Ongoing viral evolution in immunocompromised individuals with persistent infection may facilitate the evolution of SARS-CoV-2 and emergence of variants of concern (VOC). This study was conducted in the Western Cape Province of South Africa where the HIV prevalence is around 8%, with limited information on the frequency of persistent SARS-CoV-2 infection, the pattern of evolution in these individuals, and if these...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 40910685
DOI: 10.1128/jvi.00780-25
PMCID: PMC12548466

Genes

CD4

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