Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Intra-host SARS-CoV-2 diversity in immunocompromised people living with HIV provides insight into the evolutionary trajectory of SARS-CoV-2.

Journal of virology - 23 Oct 2025

Joseph R, Marais G, Iranzadeh I, Alisoltani A, Hardie D, Davies M-A, Heekes A, Chetty N, Timmerman V, Hsiao N-Y, Williamson C

Abstract excerpt

Ongoing viral evolution in immunocompromised individuals with persistent infection may facilitate the evolution of SARS-CoV-2 and emergence of variants of concern (VOC). This study was conducted in the Western Cape Province of South Africa where the HIV prevalence is around 8%, with limited information on the frequency of persistent SARS-CoV-2 infection, the pattern of evolution in these individuals, and if these...

Topics

Humans
Immunocompromised Host
COVID-19
SARS-CoV-2
HIV Infections
Female
Male
Adult
Middle Aged
South Africa
Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome, Viral

Phylogeny

Genetic Variation

Source

Open in PubMed Open full text

Identifiers

PMID: 40910685
DOI: 10.1128/jvi.00780-25
PMCID: PMC12548466

Genes

CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intra-host SARS-CoV-2 diversity in immunocompromised people living with HIV provides insight into the evolutionary trajectory of SARS-CoV-2.PMID 40910685Read ↗

SARS-CoV-2 population dynamics in immunocompetent individuals in a closed transmission chain shows genomic diversity over the course of infection.Semantic proximity Read ↗

Cumulative SARS-CoV-2 mutations and corresponding changes in immunity in an immunocompromised patient indicate viral evolution within the host.Semantic proximity Read ↗

Intra-Host Evolution Provides for Continuous Emergence of SARS-CoV-2 VariantsSemantic proximity Read ↗

SARS-CoV-2 intra-host evolution during prolonged infection in an immunocompromised patient.Semantic proximity Read ↗

SARS-CoV-2 in an immunocompromised host: convalescent plasma therapy and viral evolution elucidated by whole genome sequencing.Semantic proximity Read ↗

Case reports of persistent SARS-CoV-2 infection outline within-host viral evolution in immunocompromised patients.Semantic proximity Read ↗

Different Within-Host Viral Evolution Dynamics in Severely Immunosuppressed Cases with Persistent SARS-CoV-2Semantic proximity Read ↗

Intra-host evolution during SARS-CoV-2 persistent infectionSemantic proximity Read ↗

Emergence of multiple SARS-CoV-2 mutations in an immunocompromised hostSemantic proximity Read ↗

SARS-CoV-2 variants in the making: Sequential intrahost evolution and forward transmissions in the context of persistent infectionsSemantic proximity Read ↗

Impact of prolonged infection on SARS-CoV-2 evolution.Semantic proximity Read ↗

Combined Effects of Severe Immunocompromise and Prolonged Virus Shedding on Within-Host SARS-CoV-2 Evolution in COVID-19Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.