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Article

Genome plasticity in Candida albicans is driven by long repeat sequences

7 Jun 2019

Abstract excerpt

Genome rearrangements resulting in copy number variation (CNV) and loss of heterozygosity (LOH) are frequently observed during the somatic evolution of cancer and promote rapid adaptation of fungi to novel environments. In the human fungal pathogen Candida albicans, CNV and LOH confer increased virulence and antifungal drug resistance, yet the mechanisms driving these rearrangements are not completely understood....

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PMID: 31172944
DOI: 10.7554/elife.45954

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