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Article

Influence of TRPM4 rs8104571 genotype on intracranial pressure and outcomes in African Americans with traumatic brain injury.

Scientific reports - 10 Apr 2023

Krocker Joseph D, Cotton Madeline E, Schriner Jacob B, Osborn Baron K, Talanker Michael M, Wang Yao-Wei W, Cox Charles S, Wade Charles E

Abstract excerpt

The TRPM4 gene codes for a membrane ion channel subunit related to inflammation in the central nervous system. Recent investigation has identified an association between TRPM4 single nucleotide polymorphisms (SNPs) rs8104571 and rs150391806 and increased intracranial (ICP) pressure following traumatic brain injury (TBI). We assessed the influence of these genotypes on clinical outcomes and ICP in TBI patients. We...

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Identifiers

PMID: 37037835
DOI: 10.1038/s41598-023-32819-7
PMCID: PMC10086037

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