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Article

A Boolean model explains phenotypic plasticity changes underlying hepatic cancer stem cells emergence.

NPJ systems biology and applications - 2 Sept 2024

Hernández-Magaña Alexis, Bensussen Antonio, Martínez-García Juan Carlos, Álvarez-Buylla Elena R

Abstract excerpt

In several carcinomas, including hepatocellular carcinoma, it has been demonstrated that cancer stem cells (CSCs) have enhanced invasiveness and therapy resistance compared to differentiated cancer cells. Mathematical-computational tools could be valuable for integrating experimental results and understanding the phenotypic plasticity mechanisms for CSCs emergence. Based on the literature review, we constructed a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39223160
DOI: 10.1038/s41540-024-00422-9
PMCID: PMC11369243

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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