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Article

The Wnt pathway can stabilize hybrid phenotypes in the epithelial-mesenchymal transition: A logical modeling approach.

Computational biology and chemistry - 1 Aug 2022

Silveira Daner Acunha, Gupta Shantanu, Sinigaglia Marialva, Mombach José Carlos Merino

Abstract excerpt

The Wnt pathway is important to regulate a variety of biochemical functions and can contribute to cancer development through its influence on the epithelial-mesenchymal transition (EMT). Multiple circuits have been reported to participate in the regulation of the Wnt signaling, however, the way these circuits coordinately regulate this signaling is still unclear. Moreover, the mechanisms responsible for the...

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PMID: 35763962
DOI: 10.1016/j.compbiolchem.2022.107714

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