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Mathematical modelling of phenotypic plasticity and conversion to a stem-cell state under hypoxia

3 Feb 2016

Abstract excerpt

Hypoxia, or oxygen deficiency, is known to be associated with breast tumour progression, resistance to conventional therapies and poor clinical prognosis. The epithelial-mesenchymal transition (EMT) is a process that confers invasive and migratory capabilities as well as stem cell properties to carcinoma cells thus promoting metastatic progression. In this work, we examined the impact of hypoxia on EMT-associated...

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PMID: 26838463
DOI: 10.1038/srep18074

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