Promoters Constrain Evolution of Expression Levels of Essential Genes in Escherichia coli.

doi:10.1093/molbev/msae185

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Article

Promoters Constrain Evolution of Expression Levels of Essential Genes in Escherichia coli.

Molecular biology and evolution - 4 Sept 2024

Tsuru Saburo, Hatanaka Naoki, Furusawa Chikara

Abstract excerpt

Variability in expression levels in response to random genomic mutations varies among genes, influencing both the facilitation and constraint of phenotypic evolution in organisms. Despite its importance, both the underlying mechanisms and evolutionary origins of this variability remain largely unknown due to the mixed contributions of cis- and trans-acting elements. To address this issue, we focused on the...

Topics

Escherichia coli
Promoter Regions, Genetic
Genes, Essential
Evolution, Molecular
Mutation
Selection, Genetic
Gene Expression Regulation, Bacterial
Genetic Fitness

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Identifiers

PMID: 39219319
DOI: 10.1093/molbev/msae185
PMCID: PMC11406756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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