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Article

De novo promoters emerge more readily from random DNA than from genomic DNA.

Science advances - 29 May 2026

Fuqua Timothy, Wagner Andreas

Abstract excerpt

Promoters are DNA sequences that initiate transcription. We studied the propensity of both random and genomic DNA to initiate transcription. To this end, we assayed the promoter activity of 17,129 random, synthetic DNA sequences and 91,866 Escherichia coli genomic sequences. Genomic DNA encodes ~1.3× more promoters than random DNA. This higher incidence of promoters also holds for intragenic regions, suggesting...

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Identifiers

PMID: 42213843
DOI: 10.1126/sciadv.aec2554
PMCID: PMC13220856

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