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Article

Mendelian randomization reveals potential causal relationships between cellular senescence-related genes and multiple cancer risks.

Communications biology - 31 Aug 2024

Qiu Xunan, Guo Rui, Wang Yingying, Zheng Shuwen, Wang Bengang, Gong Yuehua

Abstract excerpt

Cellular senescence is widely acknowledged as having strong associations with cancer. However, the intricate relationships between cellular senescence-related (CSR) genes and cancer risk remain poorly explored, with insights on causality remaining elusive. In this study, Mendelian Randomization (MR) analyses were used to draw causal inferences from 866 CSR genes as exposures and summary statistics for 18 common...

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Identifiers

PMID: 39215079
DOI: 10.1038/s42003-024-06755-9
PMCID: PMC11364673

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