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Druggable genome-wide Mendelian randomization integrating GWAS and eQTL/pQTL data identifies targets for lung squamous cell carcinoma

17 Aug 2025

Abstract excerpt

Lung squamous cell carcinoma (LUSC) is one of the most common types of non-small cell lung cancer with poor prognosis. Druggable genome-wide Mendelian randomization (MR) was conducted to discover LUSC-related targets using expression quantitative trait loci (eQTL) and protein QTL (pQTL) in the ieu_b_4953 dataset and finngen dataset. Bayesian co-localization analysis, summary‑data‑based MR (SMR) analysis, and...

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PMID: 40820226
DOI: 10.1038/s41598-025-15977-8

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