Multi-omics data reveal causal associations of cellular senescence-related genes in rheumatoid arthritis: A summary-data-based Mendelian randomization and co-localization analysis.

Abstract excerpt

Rheumatoid arthritis (RA) is a complex autoimmune disease. Recently, cell senescence has been identified as a key factor in its pathogenesis. This study integrated multi-omics summary data and applied Mendelian randomization (MR) and co-localization analysis to systematically evaluate the causal relationships between cell senescence-related genes and RA. We collected summary data on blood methylation quantitative...

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