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Article

Genome-wide screening with hydroxyurea reveals a link between nonessential ribosomal proteins and reactive oxygen species production.

Journal of bacteriology - 1 Mar 2013

Nakayashiki Toru, Mori Hirotada

Abstract excerpt

We performed a screening of hydroxyurea (HU)-sensitive mutants using a single-gene-deletion mutant collection in Escherichia coli. HU inhibits ribonucleotide reductase (RNR), which leads to arrest of the replication fork. Surprisingly, the wild-type was less resistant to HU than the average for the Keio Collection. Respiration-defective mutants were significantly more resistant to HU, suggesting that the...

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Identifiers

PMID: 23292777
DOI: 10.1128/JB.02145-12
PMCID: PMC3592001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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