Article
Survival estimates and their predictors in genetic frontotemporal dementia: an international, retrospective, cohort study.
The Lancet. Neurology - 1 Aug 2026
Bouzigues Arabella, Grassi Mario, Cantoni Valentina, Premi Enrico, Bellini Sonia, Binetti Giuliano, Logroscino Giancarlo, Russell Lucy L, Ferry-Bolder Eve, Foster Phoebe H, van Swieten John C, Jiskoot Lize C, Seelaar Harro, Sanchez-Valle Raquel, Laforce Robert, Graff Caroline, Galimberti Daniela, Vandenberghe Rik, de Mendonça Alexandre, Di Fede Giuseppe, Santana Isabel, Gerhard Alexander, Langheinrich Tobias, Levin Johannes, Nacmias Benedetta, Otto Markus, Bertoux Maxime, Lebouvier Thibaud, Ducharme Simon, Butler Christopher, le Ber Isabelle, Bruffaerts Rose, Solje Eino, Kinnunen Mika, Krüger Johanna, Finger Elizabeth, Tartaglia Maria Carmela, Masellis Mario, Rowe James B, Synofzik Matthis, Moreno Fermin, Ghidoni Roberta, Migliaccio Raffaella, Rohrer Jonathan D, Borroni Barbara
Abstract excerpt
BACKGROUND: What drives the heterogeneity of survival estimates in genetic frontotemporal dementia is unknown. We sought to understand the natural history and predictors of disease trajectory, which are crucial not only for effective care but also for the design of therapeutic clinical trials and efficacy evaluation. METHODS: In this international, cohort study, we used the Kaplan-Meier method to retrospectively...
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