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Article

Association of glucocerebrosidase polymorphisms and mutations with dementia in incident Parkinson's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Oct 2018

Lunde Kristin Aaser, Chung Janete, Dalen Ingvild, Pedersen Kenn Freddy, Linder Jan, Domellöf Magdalena E, Elgh Eva, Macleod Angus D, Tzoulis Charalampos, Larsen Jan Petter, Tysnes Ole-Bjørn, Forsgren Lars, Counsell Carl E, Alves Guido, Maple-Grødem Jodi

Abstract excerpt

INTRODUCTION: Both polymorphisms and mutations in glucocerebrosidase (GBA) may influence the development of dementia in patients with Parkinson's disease. METHODS: Four hundred forty-two patients and 419 controls were followed for 7 years. Dementia was diagnosed using established criteria. Participants were analyzed for GBA genetic variants, including E326K, T369M, and L444P. Associations between GBA carrier...

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Identifiers

PMID: 29792872
DOI: 10.1016/j.jalz.2018.04.006

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